Download e-book for kindle: Exploration and Analysis of DNA Microarray and Protein Array by Dhammika Amaratunga

By Dhammika Amaratunga

ISBN-10: 0471273988

ISBN-13: 9780471273981

A state-of-the-art consultant to the research of DNA microarray dataGenomics is likely one of the significant medical revolutions of this century, and using microarrays to speedily learn various DNA samples has enabled scientists to make feel of mountains of genomic info via statistical research. this present day, microarrays are getting used in biomedical examine to review such very important parts as a drug’s healing value–or toxicity–and cancer-spreading styles of gene activity.Exploration and research of DNA Microarray and Protein Array facts solutions the necessity for a entire, state-of-the-art assessment of this significant and rising box. The authors, professional researchers with huge event in either and academia, successfully define all levels of this progressive analytical process, from the preprocessing to the research stage.Highlights of the textual content include:A overview of simple molecular biology, by way of an creation to microarrays and their preparationChapters on processing scanned pictures and preprocessing microarray dataMethods for selecting differentially expressed genes in comparative microarray experimentsDiscussions of gene and pattern clustering and sophistication predictionExtension of study how you can protein array dataNumerous workouts for self-study in addition to facts units and an invaluable selection of computational instruments at the authors’ site make this significant textual content a invaluable source for either scholars and pros within the box.

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Extra resources for Exploration and Analysis of DNA Microarray and Protein Array Data (Wiley Series in Probability and Statistics)

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This is the average intensity of the pixels around the spot that were designated as background. The average used is often the mean or median. The background intensities are represented as an array { B,, } of the same dimension as { X,, }. Pixel intensity distribution. In general. the distribution of pixel intensities in and around a spot does not resemble a normal. Instead, for example, it could be peaked with one or two long tails. This is one reason why the segmentation process can sometimes be imprecise.

In what way does quantitative RT-PCR complement microarrays? Exploration and Analysis of DNA Microarray and Protein Array Data Edited by DHAMMIKA AMARATUNGA and JAVIER CABRERA Copyright 02004 by John Wiley & Sons, Inc CHAPTER 4 Processing the Scanned Image When microarrays are scanned at the end of an experiment, the result is a series of images, one image per channel. Thus a one-channel microarray, such as an oligonucleotide array, yields one image per array, whereas a two-channel microarray yields two images per array, one image per channel.

Ld shows a histogram of {log(R,)}. lc, most genes fall along the Y = X line, indicating that they are expressed to the same degree in both tissues. The differentially expressing genes are those that lie far away from the Y = X line. lb most genes have R, values close to one (and, correspondingly, in Figure 3. Id most genes have log(R,) values close to zero), again indicating that they are expressed to the same degree in both tissues. 5) indicating genes that are underexpressed or downregulated in the cancer cells.

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Exploration and Analysis of DNA Microarray and Protein Array Data (Wiley Series in Probability and Statistics) by Dhammika Amaratunga

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