By Hans A. Krebs, H.L. Kornberg, K. Burton
This survey used to be written on the invitation of the Editors of the "Ergebnisse der Physiologie". Its goal is to give the more moderen growth within the understand ledge of organic strength variations. because it used to be meant for a assessment magazine, the reader was once taken to be acquainted with the basics of present biochemistry, as defined within the usual textbooks. It used to be now not the item to collect an in depth selection of proof. The survey is restricted to points of wider curiosity, and the most emphasis has been at the common unifying ideas which emerge from the good mass of designated ob servations. the object is reprinted within the desire that it can be invaluable during this shape to complex scholars and study staff in biochemistry and similar topics. H. A. KREBS H. L. KORNBERG 2 desk of Contents web page 1. the foremost place of Adenosine Triphosphate . . . 213 2. the 3 levels of nutrition Degradation. . . . 213 three. The Energy-Yielding Steps of middleman Metabolism 215 four. The Build-up of Phosphate Bond strength ..... 221 five. substitute Pathways of Anaerobic Fermentation in Micro-organisms. 227 6. substitute Pathways of Glucose Oxidation . 237 7. the trail of Carbon in Photosynthesis . . . 243 eight. usage of power for Chemical Syntheses 249 nine. keep an eye on of Energy-Supplying methods . . . 262 10. a different characteristic of ATP as an power shop. 271 eleven. Evolution of power remodeling Mechanisms 273 Appendix via ok. BURTON loose power information of organic curiosity 27S References . . . . . . . . . . . . . . .
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Extra info for Energy Transformations in Living Matter: A Survey
The final stage in the synthesis is the esterification of fatty acids. Information on this stage is still incomplete. According to KORNBERG & PRICER ['1953 (b)], long chain acyl coenzyme A can react with oc-glycerophosphate. CHpH CHp-Acyl I I I + 2 Acyl CoA -+ CHOH I CHO-Acyl CHPP0 3H 2 CHPP03H 2 rx-glycerophosphate phosphatidic acid (8,24) How the phosphatidic acid is converted into neutral fat, or whether there is a direct pathway leading from glycerol and acyl coenzyme A to neutral fat, is not yet known (see TIETZ and SHAPIRO 1956).
A. KREBS and H. L. KORNBERG: Energy Transformations in Living Matter If glucose is completely oxidized according to Fig. 8, dehydrogenations occur at only two stages (TPN being the hydrogen acceptor in both) and CO 2 is released by one reaction only. It is indeed remarkable that all six carbon atoms of glucose can be released by this one step. Again there is an extraordinary economy of chemical tools. In the glucose breakdown by fermentation followed by the tricarboxylic acid cycle there are at least 6 different reactions leading to the reduction of pyridine nucleotide, against 2 in the pentose phosphate cycle.
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Energy Transformations in Living Matter: A Survey by Hans A. Krebs, H.L. Kornberg, K. Burton