Diagnosis and Management of Endocrine-related Tumors by Robert B. Page, Richard J. Santen (auth.), Richard J. Santen PDF

By Robert B. Page, Richard J. Santen (auth.), Richard J. Santen M.D., Andrea Manni M.D. (eds.)

ISBN-10: 1461297982

ISBN-13: 9781461297987

ISBN-10: 1461328497

ISBN-13: 9781461328490

Patients with quite a few tumors current to the health care provider due to scientific manifestations of hormones secreted in extra. This phenomenon attracted the investigative curiosity of such pioneers as Harvey Cushing who well-known that pituitary tumors can cause acromegaly and Charles Mayo who linked hyper­ rigidity with adrenal medullary neoplasms. present int~rest in endocrine-related tumors has intensified as a result of the explosive improvement of more moderen methodol­ ogy for his or her examine. particular measurements of secretory items, hybridization assays to spot items of genomic translation and quantitative review of tissue hormone receptors have supplied technique of characterizing and accurately following sufferers with endocrine-related tumors. remedies dependent upon those advances are swiftly proliferating. the present quantity makes an attempt to synthesize a lot of this contemporary details with the objective of offering a valid foundation for making scientific decisions relating to prognosis and administration. Tumors of endocrine glandular tissues normally confront practising physi­ cians with tricky administration difficulties. a number of certain beneficial properties of those tumors necessitate collaboration between quite a few area of expertise disciplines which will get to the bottom of those difficulties and to supply a excessive point of scientific care. for instance, endocrine neoplasms secrete lively hormones or hormone precursors which produce scientific manifestations so much wide-spread to endocrinologists. yes thera­ pies resembling radioactive iodine for thyroid melanoma benefit from the hormone­ responsiveness of those tumors to facilitate remedy. those features require contributors educated in endocrinology to enforce advanced diagnostic and thera­ peutic maneuvers.

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Using these criteria, the surgical therapy of 'enclosed adenomas' is far more successful than that of 'invasive adenomas' [120,153]. The completeness of removal of nonfunctioning tumors is more difficult to assess. CT scanning is the most reliable method at present by which to evaluate the amount of residual tumor following the approach to a large tumor [158]. Reliance upon visual field testing alone is not a reliable guide to the completeness of tumor removal since in the experience with large functioning adenomas visual fields may markedly improve or return to normal but hypersecretion by the residual adenoma may persist.

Classification of pituitary adenomas on the basis of plain x-ray, tomographic and CT findings is useful in choosing an approach to the tumor and in predicting the results of surgery [119]. From a radiologic viewpoint, pituitary tumors may be 20 Figure 14a. Coronal CT of normal pituitary (see Fig. 6a). Note small homogeneous pituitary gland, flat diaphragm sella, water density over superior border of gland and straight vertical pituitary stalk (white arrowhead) . Figure 14b. Microadenoma of pituitary gland.

Warner BA, Santen RJ, Page RB: Growth horomone and prolactin secretion by a tumor of the pharyngeal pituitary. Ann Int Med 96: 65-66, 1982. 82. Bergland RM: Pathological considerations in pituitary tumors. Prog Neurol Surg 6: 62-94, 1975. 83. Martinez AJ, Lee A, Moossy J, Maroon JC: Pituitary adenomas: clinicopathological and immunohistochemical study. Ann Neurol 7: 24-36, 1980. 84. Ridgway EC, Klibanski A, Ladenson PW, Clemmons D, Beitins IZ, McArthur JW, Martorana MA, Zervas NT: Pure alpha-secreting pituitary adenomas.

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Diagnosis and Management of Endocrine-related Tumors by Robert B. Page, Richard J. Santen (auth.), Richard J. Santen M.D., Andrea Manni M.D. (eds.)


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