Download PDF by Noboru Motohashi: Bioactive Heterocycles VII: Flavonoids and Anthocyanins in

By Noboru Motohashi

ISBN-10: 3642003362

ISBN-13: 9783642003363

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Additional resources for Bioactive Heterocycles VII: Flavonoids and Anthocyanins in Plants, and Latest Bioactive Heterocycles II

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W.

Quantitative Structure–Cytotoxicity Relationship 113 Fig. 6 (Fig. 11, A-8), slightly higher than the optimal logP values reported for derivatives of prenylalcohol, vitamin K2 [26], gallic acid [27] and coumarin [28] (logP of 2–3). W. 210 Length Table 6 Relationship coefficients between CC50 against the indicated cells and each chemical descriptor of 5-trifluoromethyloxazole derivatives 114 M. Ishihara et al. Quantitative Structure–Cytotoxicity Relationship 115 Fig. 12 η–χ diagram of 5-tifluoromethyloxazol derivatives.

3p). It should be noted that a straight line, instead of the usual parabolic curve, was delineated when CC50 value was plotted vs. logP in HSC-3 cells. However, there was no relationship between the CC50 and other descriptors (Table 2). We investigated the QSAR of newly synthesized imidazole derivatives in HL-60 and HSC-3 cells, based on the concept of chemical hardness. A good correlation was found between the CC50 and χ in HL-60 cells. W. 129 Quantitative Structure–Cytotoxicity Relationship 103 activity of imidazole derivatives in HL-60 cells can be estimated by the η–χ activity diagram.

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Bioactive Heterocycles VII: Flavonoids and Anthocyanins in Plants, and Latest Bioactive Heterocycles II by Noboru Motohashi


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